Albuterol/Salbutamol

Brand/Trade Names: Airomir, ProAir, Proventil, Sultanol, Xopenex, Ventolin

Description: Albuterol/Salbutamol, a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity.
Albuterol/Salbutamol is a beta(2)-adrenergic agonist. It stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that albuterol/salbutamol increases cAMP production by activating adenylate cyclase, and the actions of albuterol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentrations leads to a smooth muscle relaxation. Increased intracellular cyclic AMP concentrations also cause an inhibition of the release of mediators from mast cells in the airways.

Uses: For relief and prevention of bronchospasm due to asthma, emphysema, and chronic bronchitis.

Albuterol/Salbutamol Structural Formula


Additional Information Data And Resources:
Proair Prescribing Information
Ventolin Prescribing Information
Ventolin HFA Prescribing Information

June 16, 2007 | Filed Under COMMON DRUGS AND MEDICATIONS, • Allergy Treatment, Albuterol/Salbutamol - Airomir, Proventil, Ventolin

 

Notes

no notes under this mediacation.