Neosporin (Bacitracin + Neomycin + Polymyxin B)

Brand/Trade Names: Neosporin, Mycitracin, Topisporin

Description: Neosporin (from Neo, (Greek) new + Sporos, (Greek) seed) is the product name of an antibiotic ointment used in the prevention of infection and speeding the healing of wounds. The original ointment contains three different antibiotics: bacitracin, neomycin, and polymyxin B. Neomycin and polymyxin are effective in killing gram-negative bacteria, while bacitracin targets gram-positive bacteria; hence, this ‘triple antibiotic’ ointment covers for a wide range of bacteria which may infect wounds. However, these antibiotics are generally only used topically, because they are known for causing serious side effects (such as nephrotoxicity) when used parenterally. Even when used topically, the antibiotic ointment may cause side effects; in particular, neomycin is well-known for causing allergic reactions such as allergic contact dermatitis. Neosporin also commonly harmlessly exaggerates the pain of abrasions and external injuries.

Uses:

Cream - Neosporin (Neomycin and Polymyxin B Sulfates, and Gramicidin) Cream is indicated for: the treatment of infection in dermatologic disorders, particularly where the lesions are moist or weeping; the prophylaxis of bacterial contamination in burns, skin grafts, incisions and other clean lesions; abrasions, minor cuts and wounds, where the cream may prevent infection and permit normal healing.

Ointment - Neosporin (Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc) Ointment is indicated for all lesions which are infected or likely to become infected by bacteria.

Eye and Ear Solution Steril - Neosporin (Neomycin and Polymyxin B Sulfates, and Gramicidin) Eye and Ear Solution Sterile is indicated for the prophylaxis and treatment of eye and ear infections. Irrigating Solution Neosporin (Neomycin and Polymyxin B Sulfates) Irrigating Solution is to be diluted and used as a continuous irrigant or rinse for short-term use in the urinary bladder of abacteriuric patients to help prevent bacteriuria and gram-negative rod bacteremia associated with the use of indwelling catheters.

 

Bacitracin Structural Formula

 

Neomycin Structural Formula

 

Polymyxin B. Structural Formula


Additional Information Data And Resources:
Neosporin (for irrigation) Prescribing Information
Neosporin (ophthalmic solution) Prescribing Information
Neosporin - Product Monograph