Ofloxacin

Brand/Trade Names: Exocin, Floxal, Floxin, Ocuflox, Oflin, Oflocet, Oflox, Tarivid, Uro Tarivid and many more…

Description: Ofloxacin is a quinolone/fluoroquinolone antibiotic drug. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Ofloxacin acts on DNA gyrase, an enzyme which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription.

Uses: For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea and is an alternative treatment to ciprofloxacin for anthrax.

Ofloxacin Structural Formula


Additional Information Data And Resources:
Floxin Otic Solution Prescribing Information
Floxin Tablets Prescribing Information