Piperacillin, Piperacillin+Tazobactam

Brand/Trade Names: Pipracil, Tazocin (Piperacillin+Tazobactam), Zosyn (Piperacillin+Tazobactam)

Description: Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name “penicillin” can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Piperacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of piperacillin results from the inhibition of cell wall synthesis and is mediated through piperacillin binding to penicillin binding proteins (PBPs). Piperacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that piperacillin interferes with an autolysin inhibitor.

Piperacillin is normally used together with a beta-lactamase inhibitor such as tazobactam, the combination has activity against many Gram-positive and Gram-negative pathogens and anaerobes, including Pseudomonas aeruginosa.

Uses: For the treatment of polymicrobial infections.
Nasal Spray is indicated for the treatment of the symptoms of seasonal allergic rhinitis such as rhinorrhea, sneezing, and nasal pruritus in adults and children 5 years and older, and for the treatment of the symptoms of vasomotor rhinitis, such as rhinorrhea, nasal congestion and postnasal drip in adults and children 12 years and older.

Piperacillin Structural Formula Tazobactam Structural Formula


Additional Information Data And Resources:
Pipracil Prescribing Information
Zosyn Prescribing Information