Desloratadine

Brand/Trade Names: Aerius, Claramax, Clarinex

Description: Desloratadine is a long-lasting antihistamine. Desloratadine is a second-generation H1-receptor antagonist which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, for example, swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be “activated,” releasing other chemicals which produce the effects that we associate with allergy. Desloratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, desloratadine does not enter the brain from the blood and, therefore, does not cause drowsiness.
Like other H1-blockers, desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Uses: For the relief of symptoms of seasonal allergic rhinitis, pruritus, reduction in the number of hives in patients with chronic idiopathic urticaria.

Desloratadine Structural Formula


Additional Information Data And Resources:
Clarinex Prescribing Information
Clarinex Label

June 14, 2007 | Filed Under COMMON DRUGS AND MEDICATIONS, • Allergy Treatment, Desloratadine - Aerius, Clarinex, Claramax

 

Notes

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