Penicillin V

Brand/Trade Names: Beepen-Vk, Betapen-Vk, Ledercillin Vk, Ospen, Pen-V,
Pen-Vee K, Robicillin VK, V-Cillin K, Veetids

Description: Penicillin V is a penicillin beta-lactam antibiotic drug used in the treatment of many bacterial infections caused by susceptible, usually gram-positive, organisms. The name “penicillin” can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin V has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin V results from the inhibition of cell wall synthesis and is mediated through penicillin V binding to penicillin binding proteins (PBPs). Penicillin V is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin V inhibits the third and last stage of bacterial cell wall synthesis.
Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that penicillin V interferes with an autolysin inhibitor.

Uses: For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms.